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Effect of Combined Statin and Antihypertensive Therapy in Patients with Hypertension: A Systematic Review and

Ying Wang1,2, Long Jiang3, Shu-Jun Feng4

  • 1The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.

Cardiology
|October 28, 2020
PubMed

Insights

Combined statin and antihypertensive therapy significantly lowers major cardiovascular events, myocardial infarction, and stroke risk in hypertensive patients. This combination offers greater cardiovascular benefits than antihypertensive therapy alone.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Statins and antihypertensive medications are commonly prescribed to manage cardiovascular risk.

Approach:

  • A systematic meta-analysis of 8 randomized controlled trials involving 38,618 patients.
  • Compared combined statin and antihypertensive therapy against antihypertensive therapy alone.
  • Utilized relative risks (RRs) with 95% confidence intervals (CIs) and a random-effects model.

Key Points:

  • Combined therapy significantly reduced major adverse cardiovascular events (RR 0.79).
  • Reduced risk of myocardial infarction (RR 0.67) and stroke (RR 0.82).
  • No significant difference in cardiac death or all-cause mortality.

Conclusions:

  • Combined statin and antihypertensive therapy provides significant cardiovascular benefits.
  • This therapeutic approach is superior to antihypertensive therapy alone for preventing major cardiovascular events.
Abstract

Keywords:
Antihypertensive therapyCardiovascular outcomesHypertensionMeta-analysisStatin

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