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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
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Complement System: Promoter or Suppressor of Cancer Progression?
Margot Revel1, Marie V Daugan1, Catherine Sautés-Fridman1
1Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France.
Antibodies (Basel, Switzerland)
|October 29, 2020
Summary
The complement system, part of innate immunity, has dual roles in cancer, acting as both pro- and anti-tumoral. Understanding its context-dependent functions is key for targeted cancer therapies.
Area of Science:
- Immunology
- Oncology
- Molecular Biology
Background:
- The complement system, a crucial component of innate immunity, is present within the tumor microenvironment.
- While traditionally associated with pathogen clearance and homeostasis, complement's role in cancer is complex and multifaceted.
- Evidence indicates both pro-tumoral and anti-tumoral functions depending on the specific cancer type and context.
Purpose of the Study:
- To review and clarify the context-dependent role of the complement system in human cancers.
- To synthesize current knowledge on complement's dual functions in various cancer types.
- To highlight insights gained from mouse models regarding complement's impact on cancer progression.
Main Methods:
- Literature review and synthesis of recent studies on complement and cancer.
- Analysis of diverse cancer types and their interactions with complement pathways.
- Classification of human cancers based on the prognostic impact of complement gene overexpression.
Main Results:
- Complement exhibits context-dependent functions in cancer, acting as either pro-tumoral or anti-tumoral.
- Different cancer types and even models of the same cancer type show opposing effects of complement.
- A classification system based on complement gene prognostic impact has been developed.
Conclusions:
- The complex interplay between complement and cancer necessitates a nuanced understanding for therapeutic strategies.
- Targeting the complement system holds significant therapeutic potential in selected cancer patient subgroups.
- Further research is needed to fully unravel the intricate roles of complement in oncogenesis.
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