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Updated: Dec 3, 2025

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro
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Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Published on: January 25, 2017

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Multinucleated Giant Cell Formation as a Portal to Chronic Bacterial Infections

Jacob L Stockton1, Alfredo G Torres1,2

  • 1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Microorganisms
|October 29, 2020
PubMed

Insights

This review examines chronic bacterial infections, focusing on Burkholderia pseudomallei and its role in forming multi-nucleated giant cells (MNGC). These cells are key to melioidosis pathology and chronic infection development.

Area of Science:

  • Microbiology
  • Immunology
  • Pathology

Background:

  • Chronic bacterial infections pose significant health challenges.
  • Melioidosis, caused by Burkholderia pseudomallei, is a significant chronic infection.
  • Multi-nucleated giant cells (MNGC) are implicated in chronic inflammation and granuloma formation.

Purpose of the Study:

  • To review the role of MNGC in melioidosis pathogenesis.
  • To compare melioidosis MNGC formation with that in tuberculosis.
  • To explore factors influencing MNGC formation and their clinical relevance.

Main Methods:

  • Literature review and comparative analysis.
  • Examination of host-pathogen interactions.
  • Pathogenesis pathway elucidation.

Main Results:

  • Burkholderia pseudomallei actively induces MNGC formation within host tissues.
  • MNGC contribute to pyogranulomatous lesion development in melioidosis.
  • Similarities and differences in MNGC roles exist between melioidosis and tuberculosis.

Conclusions:

  • MNGC are critical players in the chronic progression and pathology of melioidosis.
  • Understanding MNGC formation mechanisms is vital for developing new therapeutic strategies.
  • Further research is needed to fully delineate MNGC function in chronic infections.
Keywords:
Burkholderia pseudomalleiMycobacterium tuberculosischronic infectionmulti nucleated giant cellpersistence

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