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The effect of DOCA and 9 alpha-fludrocortisone on renal renin content and production
J Menting1, T Morgan, G Barrett
1Department of Physiology, University of Melbourne, Parkville, Australia.
Clinical and Experimental Pharmacology & Physiology
|March 1, 1987
Abstract:
1. DOCA and 9 alpha-fludrocortisone were given to rats. 2. Plasma renin fell rapidly with both treatments. 3. Renal renin fell slowly to a low level. 4. Renal renin fell to a lower level with DOCA than with 9 alpha-fludrocortisone. 5. When DOCA and 9 alpha-fludrocortisone were stopped plasma renin levels rose rapidly and the renal renin levels increased. 6. The data suggest that synthesis is altered rapidly but it takes a prolonged time for the kidney to become depleted of renin due to the high tissue stores and the associated inhibition of release.