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First-degree atrioventricular block in acute anterior myocardial infarction

Arvin Zabeh1, Masoumeh Jahanafrouz1, Babak Kazemi1

  • 1Cardiovascular Research Center, Tabriz University of Medical Science, Madani Heart Center, Cardiology Department, Tabriz, Iran.

Asian Cardiovascular & Thoracic Annals
|October 29, 2020
PubMed

Insights

First-degree atrioventricular block in patients with acute anterior myocardial infarction indicates a worse prognosis. This condition, characterized by a prolonged PR interval, is linked to higher hospital mortality rates in these patients.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Research

Background:

  • Limited data exists on the prognostic significance of first-degree atrioventricular block in acute anterior myocardial infarction.
  • This study investigates the association between prolonged PR interval and clinical outcomes in patients treated with thrombolysis.

Purpose of the Study:

  • To determine the prognostic implications of first-degree atrioventricular block in patients with acute anterior ST-segment elevation myocardial infarction.
  • To elucidate the association between prolonged PR interval and hospital clinical outcomes in patients receiving thrombolytic therapy.

Main Methods:

  • Retrospective analysis of 300 consecutive patients with first acute anterior ST-segment elevation myocardial infarction treated with thrombolysis.
  • Patients were divided into two groups based on admission PR interval: ≤200 ms and >200 ms.
  • Comparison of hospital mortality and complications between the two groups.

Main Results:

  • 26 (8.66%) patients presented with first-degree atrioventricular block.
  • Hospital mortality was significantly higher in patients with PR interval >200 ms (26.9%) compared to those with PR interval ≤200 ms (4.7%; p < 0.001).
  • Multivariate analysis identified PR interval (OR = 1.031; 95% CI: 1.008-1.056; p = 0.009) and left ventricular systolic function as independent predictors of hospital mortality.

Conclusions:

  • First-degree atrioventricular block is associated with increased hospital mortality in patients with acute anterior ST-segment elevation myocardial infarction treated with thrombolysis.
  • A prolonged PR interval serves as an independent predictor of worse prognosis in this patient cohort.
Abstract

Keywords:
Electrocardiographyheart blockmortalitymyocardial infarction

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