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Role of Platelets in Detection and Regulation of Infection

Irina Portier1, Robert A Campbell1,2

  • 1University of Utah Molecular Medicine Program, Salt Lake City (I.P., R.A.C.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|October 29, 2020
PubMed

Platelets are classically known as essential mediators of hemostasis and thrombosis. However, in recent years, platelets have gained recognition for their inflammatory functions, which modulate the immune response during infectious diseases. Platelets contain various immunoreceptors that enable them to act as sentinels to recognize intravascular pathogens. Upon activation, platelets directly limit pathogen growth through the release of AMPs (antimicrobial proteins) and ensure pathogen clearance through activation of immune cells. However, aberrant platelet activation can lead to inflammation and thrombotic events.

Keywords:
blood plateletshemostasisimmunologyinfectioninflammation

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