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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma
Sisi Deng1, Zhi Zhang1, Xiaoli Lu1
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R. China.
Abstract:
GTPase of immunity-associated proteins (GIMAPs) are frequently prescribed as important components of immune regulation complexes, which were known to play key roles in lung adenocarcinoma. However, little is known about the function of distinct GIMAPs in lung adenocarcinoma. To address this issue, this study investigated the biological function and pathway of GIMAPs in lung adenocarcinoma using multiple public databases. Absent expression of GIMAPs was found in lung adenocarcinoma at mRNA and protein levels. While a purity-corrected value uncovered that all GIMAPs were positively associated with the immune infiltration of lung adenocarcinoma. Furthermore, the expressions of GIMAPs were considered to be negatively associated with clinical cancer stages, patient's gender and pathological tumor grades in patients with lung adenocarcinoma. Besides, higher mRNA expression of GIMAPs was significantly associated with longer overall survival of patients with lung adenocarcinoma. Taken together, these results may enable GIMAPs family members as diagnostic and survival biomarker candidates or even potential therapeutic targets for patients with lung adenocarcinoma.
Insights
GTPase of immunity-associated proteins (GIMAPs) are underexpressed in lung adenocarcinoma but correlate with increased immune infiltration. Higher GIMAP expression predicts better patient survival, suggesting their potential as biomarkers.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- GTPase of immunity-associated proteins (GIMAPs) are integral to immune regulation.
- Their specific roles in lung adenocarcinoma pathogenesis remain largely uncharacterized.
- Understanding GIMAP function is crucial for advancing lung cancer research.
Purpose of the Study:
- To elucidate the biological functions and pathways of GIMAPs in lung adenocarcinoma.
- To investigate the association between GIMAP expression and key clinicopathological features.
- To evaluate GIMAPs as potential diagnostic and prognostic markers for lung adenocarcinoma.
Main Methods:
- Utilized multiple public databases for comprehensive analysis.
- Assessed GIMAP expression at both mRNA and protein levels.
- Correlated GIMAP expression with immune infiltration, clinical stage, tumor grade, and patient survival.
Main Results:
- GIMAP expression was significantly reduced in lung adenocarcinoma tissues.
- All GIMAPs showed a positive correlation with immune cell infiltration in tumors.
- Higher GIMAP mRNA levels were linked to less advanced clinical stages, lower tumor grades, and improved overall survival.
Conclusions:
- GIMAPs exhibit altered expression patterns in lung adenocarcinoma.
- GIMAPs are associated with immune infiltration and favorable clinical outcomes.
- GIMAP family members represent promising candidates for diagnostic biomarkers, prognostic indicators, and potential therapeutic targets in lung adenocarcinoma.
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