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Is amiloride a promising cardiovascular medication to persist in the COVID-19 crisis?

Mir S Adil1, S Priya Narayanan1, Payaningal R Somanath1

  • 1Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA.

Drug Discoveries & Therapeutics
|October 29, 2020
PubMed

Insights

Amiloride may be an ideal COVID-19 treatment due to its effects on angiotensin-converting enzyme (ACE) and cytosolic pH. This drug offers a promising alternative or add-on therapy for patients, potentially improving outcomes.

Area of Science:

  • Pharmacology
  • Virology
  • Cardiovascular Medicine

Background:

  • The COVID-19 pandemic necessitates evidence-based therapeutic strategies.
  • Patients with hypertension and diabetes using ACE inhibitors face uncertainty regarding SARS-CoV-2.
  • ACE inhibitors may increase ACE2, facilitating SARS-CoV-2 entry.

Purpose of the Study:

  • To evaluate amiloride as a potential therapeutic agent for COVID-19.
  • To explore amiloride's effects on ACE levels and cytosolic pH in the context of COVID-19.

Main Methods:

  • Review of existing literature on amiloride's pharmacological properties.
  • Analysis of amiloride's potential interactions with SARS-CoV-2 mechanisms.
  • Assessment of amiloride's known effects on ACE and pH.

Main Results:

  • Amiloride demonstrates potential to reduce ACE levels.
  • Amiloride increases cytosolic pH, a beneficial effect.
  • Its potassium-sparing and anti-epileptic properties are noted.

Conclusions:

  • Amiloride presents a promising candidate for COVID-19 treatment.
  • It may serve as an alternative or combinatorial therapy.
  • Further research is warranted to validate its efficacy and safety in COVID-19 patients.

Keywords:
ACE inhibitorsACE2COVID-19ENaCamiloridecytosolic pH

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