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Study on Precipitating Factor of Chronic Hepatic Encephalopathy
M H Ali1, M A Kabir, M S Islam
1Dr Md Haidar Ali, Registrar, Department of Medical Oncology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh;
Mymensingh Medical Journal : MMJ
|October 29, 2020
Summary
This study identified key factors precipitating hepatic encephalopathy (HE) in chronic liver disease patients. Electrolyte imbalance, constipation, infections, and gastrointestinal bleeding are the most common triggers for HE.
Area of Science:
- Hepatology
- Neurology
- Gastroenterology
Background:
- Hepatic encephalopathy (HE) is a serious neuro-psychiatric complication of chronic liver disease.
- It significantly contributes to global morbidity and mortality.
- While exact mechanisms are unclear, precipitating factors are widely recognized.
Purpose of the Study:
- To explore and identify the common precipitating factors of chronic hepatic encephalopathy.
- To understand the clinical profile of patients with hepatic encephalopathy.
Main Methods:
- A cross-sectional descriptive study was conducted at Mymensingh Medical College Hospital, Bangladesh.
- One hundred patients diagnosed with hepatic encephalopathy associated with liver cirrhosis were enrolled.
- Data collection occurred from April 2016 to October 2016.
Main Results:
- The mean age of patients was 52.81±8.15 years, with 66.0% being male.
- Common precipitating factors included electrolyte imbalance (hyponatremia 34.0%, hypokalemia 28.0%), constipation (37.0%), infections (20.0%), and gastrointestinal bleeding (14.0%).
- Biochemical abnormalities revealed low hemoglobin (70.0%), low platelet count (68.0%), and low serum albumin (98.0%).
Conclusions:
- Electrolyte imbalance, constipation, infections, upper gastrointestinal bleeding, and diuretic use are the most frequent precipitating factors for hepatic encephalopathy.
- Identifying and managing these factors is crucial for patient outcomes.
- Further research into HE mechanisms and management is warranted.
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