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Published on: June 11, 2019
A lymphoproliferative pericardial mass
Barbara Mantilla1, Myrian Vinan-Vega1, Kenneth Nugent1
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.
Insights
Castleman disease (CD) is a rare lymphoproliferative disorder. This case highlights a unicentric hyaline-vascular variant presenting as an incidental pericardial mass, posing surgical challenges due to potential vital structure compression.
Area of Science:
- Pathology
- Oncology
- Cardiology
Background:
- Castleman disease (CD) is a rare lymphoproliferative disorder with diverse clinical presentations and prognoses.
- The hyaline-vascular variant of unicentric CD typically presents as a mediastinal mass and is associated with favorable outcomes.
- While often asymptomatic and resectable, surgical intervention can be complicated by compression of adjacent vital structures.
Abstract:
Castleman disease (CD) is a rare lymphoproliferative disorder with variable presentation and prognosis. Most CD cases are unicentric and correspond to the hyaline-vascular variant, a histopathological classification associated with better outcomes, which commonly presents as an enhancing hypervascular mediastinal mass. CD is often asymptomatic and surgically resectable. Nonetheless, surgical resection can be difficult when the lymphoid mass is causing compression of vital structures. We discuss a rare case of hyaline-vascular unicentric CD presenting as an incidental pericardial mass.
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