Total Antioxidant Status in Stable Chronic Obstructive Pulmonary Disease

Area of Science:

• Pulmonary Medicine
• Biochemistry

Background:

• Chronic Obstructive Pulmonary Disease (COPD) is associated with oxidative stress.
• Inconsistent findings exist regarding total antioxidant status (TAS) in COPD patients.

Purpose of the Study:

• To evaluate total antioxidant status (TAS) in plasma of stable COPD patients.
• To compare TAS between COPD patients and controls, considering various clinical factors.

Main Methods:

• Compared TAS in 90 COPD patients and 30 controls.
• Analyzed TAS based on airway obstruction severity, gender, smoking status, pack-years, exacerbations, nutritional status, and hypercapnia.

Main Results:

• TAS was significantly higher in COPD patients than controls (P=0.03).
• TAS was significantly higher in male COPD patients than female COPD patients (P=0.001).
• TAS positively correlated with pack-years (P=0.004) and predicted COPD (OR=26.01, P=0.04).

Conclusions:

• TAS is a significant predictor of COPD.
• Higher TAS in COPD patients, particularly men, warrants further investigation.
• Time from last exacerbation may be relevant for oxidant-antioxidant balance analysis in COPD.