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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
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Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation,
May Bin-Jumah1, Sadaf Jamal Gilani2, Mohammed Asadullah Jahangir3
1Biology Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
International Journal of Nanomedicine
|October 29, 2020
Summary
This study developed optimized clarithromycin-loaded chitosan nanoparticles (CTM-CHNPs) for ocular delivery. The nanoparticles demonstrated enhanced antibacterial efficacy and corneal permeation, offering a promising treatment for bacterial conjunctivitis.
Area of Science:
- Nanotechnology
- Ophthalmology
- Microbiology
Background:
- Conventional topical drug delivery systems often suffer from low bioavailability.
- Chitosan nanoparticles offer a potential solution for improving ocular drug delivery.
Purpose of the Study:
- To prepare and optimize clarithromycin-loaded chitosan nanoparticles (CTM-CHNPs) for enhanced ocular efficacy.
- To evaluate the physicochemical properties and antimicrobial activity of CTM-CHNPs.
Main Methods:
- CTM-CHNPs were prepared using the ionotropic gelation method.
- Formulation optimization was performed using Box-Behnken design.
- Evaluated parameters included particle size, entrapment efficiency, in-vitro release, ex-vivo permeation, and antibacterial activity.
Main Results:
- Optimized CTM-CHNPs exhibited a particle size of 152±5 nm, high encapsulation efficiency (70.05%), and positive zeta potential (+35.2 mV).
- Sustained drug release (82.98% in 12 hours) and a 2.7-fold increase in corneal permeation were observed.
- CHNPs showed no corneal damage and significantly enhanced antibacterial susceptibility compared to clarithromycin solution.
Conclusions:
- Optimized CTM-CHNPs are effective for managing bacterial conjunctivitis.
- The nanoparticles increase precorneal residence time, improving therapeutic outcomes.
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