Related Experiment Video
Updated: Dec 3, 2025

09:14
Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
2.6K
Extremely Acute-Onset Cerebral Fat Embolism.
1Department of Intensive Care Medicine, Aso Iizuka Hospital, Fukuoka 820-8505, Japan.
International Journal of General Medicine
|October 29, 2020
Summary
Cerebral fat embolism (CFE) can rapidly cause coma after long bone fractures, often within an hour. This case highlights the need to consider CFE in sudden post-trauma consciousness loss.
Area of Science:
- Neurology
- Trauma Medicine
- Radiology
Background:
- Fat embolism syndrome (FES) is a post-traumatic complication typically following long bone fractures.
- Neurological involvement in FES, known as cerebral fat embolism (CFE), usually manifests 24-72 hours post-injury.
Observation:
- An elderly female with a femur fracture experienced sudden coma 55 minutes post-trauma.
- Initial CT scans were normal; MRI revealed a characteristic "starfield" pattern of hyperintense lesions on diffusion-weighted imaging.
- Petechiae were observed, and the patient remained comatose for 4 months.
Findings:
- The patient was diagnosed with CFE, presenting unusually rapidly after trauma.
- The rapid onset of CFE, less than an hour after injury, challenges the typical presentation timeline.
Implications:
- CFE should be suspected in cases of sudden consciousness deterioration shortly after long bone fractures.
- Early consideration of CFE is crucial for timely diagnosis and management in trauma patients.
- This case underscores the potential for rapid neurological decline in CFE.
Related Concept Videos
Pulmonary Embolism I: Introduction
308
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
308
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
142
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
142
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
235
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
235
Acute Respiratory Failure-III
565
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
565
Acute Coronary Syndrome I: Introduction
438
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
438

