Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolism of nitroaromatic compounds.

D E Rickert1

  • 1Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709.

Drug Metabolism Reviews
|January 1, 1987
PubMed
Summary

Nitroaromatic compounds are metabolized through nitro group reduction or glutathione replacement, with pathways varying by structure. Intestinal bacteria and liver enzymes play key roles in these biotransformations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determination of the tissue distribution and excretion by accelerator mass spectrometry of the nonadecapeptide 14C-Moli1901 in beagle dogs after intratracheal instillation.

Chemico-biological interactions·2005
Same author

The absorption and first-pass metabolism of [14C]-1,3-dinitrobenzene in the isolated vascularly perfused rat small intestine.

Biopharmaceutics & drug disposition·1996
Same author

The pharmacokinetics and extra-hepatic clearance of remifentanil, a short acting opioid agonist, in male beagle dogs during constant rate infusions.

Drug metabolism and disposition: the biological fate of chemicals·1996
Same author

Metabolism of [14C]1,3-dinitrobenzene by rat small intestinal mucosa in vitro.

Drug metabolism and disposition: the biological fate of chemicals·1995
Same author

Diminished drug metabolism due to hormonal effects of cobalt mesoporphyrin on flavoproteins.

Chemico-biological interactions·1993
Same author

Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans.

Toxicology and applied pharmacology·1992

Area of Science:

  • Biochemistry
  • Toxicology
  • Pharmacology

Background:

  • Nitroaromatic compounds exhibit complex metabolic pathways.
  • Understanding these pathways is crucial for assessing toxicity and drug interactions.

Purpose of the Study:

  • To elucidate the major metabolic routes for nitrobenzene and its derivatives.
  • To investigate the roles of different enzymes and microorganisms in nitroaromatic metabolism.

Main Methods:

  • Analysis of metabolic products from various nitroaromatic compounds.
  • Investigation of enzymatic and microbial biotransformation processes.

Main Results:

  • Two primary metabolic pathways identified: nitro group reduction and glutathione replacement.
  • Metabolic routes are highly dependent on the specific nitroaromatic compound's structure and substitution.
  • Intestinal microflora and hepatic enzymes contribute significantly to nitroaromatic metabolism.

Conclusions:

  • Nitroaromatic compound metabolism is diverse, influenced by isomerism and functional groups.
  • Further research into these pathways can enhance understanding of xenobiotic metabolism.

Related Experiment Videos