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Sleep Duration and Stroke: A Mendelian Randomization Study.

Hui Lu1, Peng-Fei Wu2,3, Rui-Zhuo Li4

  • 1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Frontiers in Neurology
|October 29, 2020
PubMed
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This summary is machine-generated.

This study found no causal link between sleep duration and overall stroke risk. While short sleep showed a weak association with cardio-embolic stroke and long sleep with large artery stroke, these were not statistically significant after adjustments.

Area of Science:

  • Genetics
  • Epidemiology
  • Sleep Science

Background:

  • Sleep duration is a modifiable behavior with potential health implications.
  • Understanding the causal relationship between sleep duration and stroke is crucial for public health.
  • Previous observational studies suggest associations, but causal evidence is limited.

Purpose of the Study:

  • To investigate the causal effect of genetically predicted sleep duration on the risk of stroke and its subtypes.
  • To utilize a Mendelian randomization approach for robust causal inference.

Main Methods:

  • Employed a two-sample Mendelian randomization (MR) design using genome-wide association study data from UK Biobank (n=446,118) for sleep traits.
  • Utilized summary-level stroke data from the MEGASTROKE consortium.
Keywords:
genome-wide association studymendelian randomizationsingle nucleotide polymorphismsleep durationstroke

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  • Applied various MR methods including inverse-variance-weighted, weighted median, MR-Egger, and MR-PRESSO, with sensitivity analyses.

    • Main Results:

    • No significant causal association was detected between genetically predicted sleep duration and overall stroke risk.
    • Weak, non-significant associations were observed for short sleep with cardio-embolic stroke and long sleep with large artery stroke after Bonferroni correction.
    • Sensitivity analyses confirmed the robustness of the null findings.

    Conclusions:

    • Sleep duration is unlikely to be causally associated with the risk of stroke or its major subtypes.
    • The findings suggest that interventions targeting sleep duration may not be effective for stroke prevention based on current genetic evidence.