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MSP-RON Pathway: Potential Regulator of Inflammation and Innate Immunity

Lingtong Huang1, Xueling Fang1, Danrong Shi2

  • 1Department of Critical Care Units, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Immunology
|October 29, 2020
PubMed

Insights

Macrophage-stimulating protein (MSP) and its receptor (RON) regulate immune responses, impacting inflammation and autoimmune diseases. This pathway is crucial for tissue stability and tumor immune evasion.

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • Macrophage-stimulating protein (MSP) is the sole ligand for recepteur d'origine nantais (RON), a MET proto-oncogene family member.
  • The MSP-RON signaling pathway influences tumor behavior and immune system diseases.

Purpose of the Study:

  • To summarize the multifaceted roles of the MSP-RON signaling pathway in immunity.
  • To highlight its implications in inflammation, autoimmune diseases, and the tumor immune microenvironment.

Main Methods:

  • Literature review of recent findings on MSP-RON signaling.
  • Analysis of MSP-RON's involvement in macrophage activation and inflammatory responses.
  • Examination of MSP-RON's association with chronic inflammation, autoimmune conditions, and tumor immunity.

Main Results:

  • MSP-RON activation inhibits nitric oxide synthesis and lipopolysaccharide-induced inflammation in macrophages.
  • The pathway is implicated in chronic liver inflammation and may affect metabolic processes.
  • Evidence links MSP-RON to autoimmune diseases, suggesting therapeutic potential.
  • MSP-RON is vital for tissue microenvironment stability and facilitates tumor immune escape.

Conclusions:

  • The MSP-RON pathway is a significant regulator of diverse immune responses.
  • It plays a critical role in inflammatory and autoimmune diseases.
  • Understanding MSP-RON's function provides a basis for future research in therapeutic development and immune modulation.
Keywords:
MSPRONautoimmune diseaseinflammationinnate immunitymacrophage

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