Insulin Autoimmune Syndrome - A Case Series

Area of Science:

• Endocrinology
• Immunology

Background:

• Insulin autoimmune syndrome (IAS), or Hirata's disease, is a rare autoimmune disorder.
• It presents as recurrent hypoglycemia due to autoantibodies against insulin.

Observation:

• This abstract details two cases of IAS diagnosed and managed at our institute.
• IAS is characterized by spontaneous hypoglycemic episodes without exogenous insulin administration.

Findings:

• The majority of IAS cases occur in the Japanese population, with rare occurrences in other ethnicities.
• The two reported cases highlight the diagnostic challenges and management of IAS.

Implications:

• Recognizing IAS is vital to avoid misdiagnosis and unnecessary investigations.
• This report contributes to understanding IAS in non-Japanese populations and emphasizes timely diagnosis.