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Treatment of Post-Hypoxic Myoclonus using Pallidal Deep Brain Stimulation Placed Using Interventional MRI Methods
Fay Gao1, Jill L Ostrem1, Doris D Wang2
1Department of Neurology, Movement Disorders and Neuromodulation Center, Weill Institute of Neurosciences, University of California, San Francisco, San Francisco, CA, US.
Deep brain stimulation (DBS) improved severe post-hypoxic myoclonus in a drowning survivor. This study highlights MRI-guided DBS for refractory myoclonus after brain injury.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Post-hypoxic myoclonus (PHM) involves debilitating muscle jerks after brain injury.
- PHM is often resistant to standard medical treatments.
- Deep brain stimulation (DBS) is an option for some movement disorders, but its use in PHM is limited.
Observation:
- A 33-year-old woman experienced severe, generalized myoclonus following cardiac arrest due to drowning.
- The patient underwent MRI-guided, asleep bilateral pallidal DBS placement.
- Action myoclonus showed improvement one year after the procedure.
Findings:
- This case adds to the evidence supporting DBS for PHM.
- The use of interventional MRI for guiding DBS lead placement was successful.
- The technique ensured safe and accurate lead implantation.
Implications:
- MRI-guided asleep DBS is a viable option for treating refractory PHM.
- This approach may offer a new therapeutic avenue for patients with severe post-hypoxic myoclonus.
- Further research is warranted to explore DBS efficacy in PHM.
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