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Clinical features of patients undergoing hemodialysis with COVID-19

Ming Tian1, Hua Li1, Ting Yan2

  • 1Department of Nephrology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

Seminars in Dialysis
|October 29, 2020
PubMed

Insights

Hemodialysis patients with COVID-19 often show lymphocytopenia and lung opacities, but these signs aren't unique. Early treatment is key to reducing mortality and infection risk in this vulnerable group.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pulmonology

Background:

  • Patients undergoing hemodialysis face increased susceptibility to infections, including coronavirus disease 2019 (COVID-19).
  • Understanding the specific clinical and epidemiological profile of COVID-19 in hemodialysis patients is crucial for effective management.

Purpose of the Study:

  • To describe the epidemiological and clinical characteristics of hemodialysis patients with COVID-19.
  • To identify mortality-related risk factors in this patient population.

Main Methods:

  • A retrospective study comparing 49 hemodialysis patients with COVID-19 (Group 1) to 74 uninfected hemodialysis patients (Group 2).
  • Analysis of demographic data, comorbidities, clinical symptoms, laboratory results (blood routine, lymphocyte subsets), and chest CT findings.

Main Results:

  • The median age of infected patients was 62 years, with 59.3% males and a median dialysis vintage of 26 months.
  • Common symptoms included fever (32.7%) and dry cough (46.9%); 18.4% were asymptomatic. Lymphocytopenia and reduced lymphocyte subsets were observed.
  • Chest CT scans revealed ground-glass opacity (45.8%) and patchy shadowing (35.4%), findings not exclusive to COVID-19 in this cohort.

Conclusions:

  • Lymphocytopenia and specific CT findings are common in hemodialysis patients with COVID-19 but lack specificity.
  • Early intervention and management of nosocomial infections are vital for reducing mortality and SARS-CoV-2 infection risk in hemodialysis patients.

Keywords:
SARS-CoV-2clinical featurescoronavirus disease 2019hemodialysis

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