Related Experiment Video

Updated: Dec 3, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.7K

Identification of key genes and pathways for melanoma in the TRIM family

YiJun Xia1, Jun Zhao2, Chunjun Yang2

  • 1Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.

Cancer Medicine
|October 29, 2020
PubMed

Insights

This study investigated the role of TRIM family proteins in melanoma development. TRIM27 expression was found to be a significant prognostic marker for melanoma survival.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Members of the TRIM (Tripartite Motif) family exhibit altered expression and prognostic significance in various cancers.
  • The specific roles of TRIM family members in melanoma development and progression are not well understood.

Purpose of the Study:

  • To investigate the expression patterns and prognostic value of TRIM family members in melanoma.
  • To identify potential TRIM-based biomarkers for melanoma diagnosis and prognosis.

Main Methods:

  • Utilized bioinformatics databases including Oncomine, UCSC, Human Protein Atlas, DAVID, and GEPIA for expression analysis.
  • Performed quantitative real-time PCR (qRT-PCR) for validation.
  • Conducted survival analysis to assess the impact of TRIM expression on patient outcomes.

Main Results:

  • Differential expression of TRIM2, TRIM7, TRIM8, TRIM18 (MID1), TRIM19 (PML), TRIM27, and TRIM29 was observed in melanoma.
  • TRIM7 and TRIM29 expression may aid in distinguishing primary tumors from metastases.
  • TRIM27 expression significantly correlated with overall survival and disease-free survival in melanoma patients.

Conclusions:

  • TRIM family proteins, particularly TRIM27, play a crucial role in melanoma development and progression.
  • TRIM27 expression level serves as a potential prognostic biomarker for melanoma.
Keywords:
GEPIAOncomineTRIMmelanomaprognosis

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.2K
Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model10:23

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model

Published on: November 13, 2012

14.0K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.4K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.9K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
7.7K