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Updated: Dec 3, 2025

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Overactive bladder syndrome - focus onto detrusor overactivity.

Taras Ptashnyk1, Martin Hatzinger1, Federico L Zeller2

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|October 29, 2020
PubMed
Summary

Patients with overactive bladder (OAB) symptoms without detrusor overactivity on urodynamics are younger, have fewer symptoms, and a better quality of life. This suggests OAB may represent different disease phases or subtypes.

Keywords:
OABdetrusor instabilitydetrusor overactivityurodynamic

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Area of Science:

  • Urology
  • Nephrology
  • Gynecology

Background:

  • Overactive bladder (OAB) is a common condition characterized by urinary urgency.
  • Detrusor overactivity (DO) is often diagnosed via urodynamics but its absence in OAB patients is not well understood.
  • Understanding urodynamic differences in OAB is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To compare urodynamic findings and patient characteristics in OAB patients with and without detrusor overactivity.
  • To investigate potential differences in symptom severity and quality of life based on urodynamic findings.

Main Methods:

  • OAB patients were categorized into two groups based on urodynamic findings: with DO (Group 1) and without DO (Group 2).
  • Comparative analyses included epidemiological data, patient history, urodynamic criteria, bladder diaries, and validated questionnaires (IC-OAB, IC-OABqol).

Main Results:

  • Significant differences in age and disease duration were observed between groups.
  • Patients with DO (Group 1) reported significantly more urgency and incontinence episodes.
  • Group 1 also exhibited higher OAB symptom scores and a greater negative impact on quality of life.

Conclusions:

  • Over half of patients with OAB symptoms lack urodynamically confirmed DO.
  • Patients without DO were younger, had fewer symptoms, and a higher maximal bladder capacity.
  • These findings suggest OAB may encompass distinct subtypes or disease phases, necessitating tailored treatment approaches.