SARS-CoV-2 infection in an infant with severe dilated cardiomyopathy

Aslak Widerøe Kristoffersen1, Per Kristian Knudsen2, Thomas Møller1

  • 1Department of Paediatric Cardiology, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.

Cardiology in the Young
|October 29, 2020
PubMed

Insights

A young child with severe heart disease experienced a mild SARS-CoV-2 infection. Close monitoring and specific treatments were crucial for managing her cardiac condition during the viral illness.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Neonatal Care

Background:

  • Severe dilated cardiomyopathy in infants can result from neonatal enterovirus myocarditis.
  • Management of pediatric heart conditions often involves diuretics and inotropes like milrinone.
  • SARS-CoV-2 (COVID-19) infection presents unique challenges in immunocompromised or critically ill children.

Observation:

  • A 4.5-month-old infant with pre-existing severe dilated cardiomyopathy contracted SARS-CoV-2.
  • The child presented with high fever and gastrointestinal symptoms, indicative of a mild COVID-19 course.
  • Cardiac function, assessed via echocardiography, remained stable throughout the SARS-CoV-2 infection.

Findings:

  • Despite a mild presentation of SARS-CoV-2, the infant required intensive monitoring.
  • Treatment focused on hemodynamic stability, including maintaining normal heart rate and fluid balance.
  • The underlying severe cardiac condition necessitated a compound treatment approach.

Implications:

  • Even mild SARS-CoV-2 infections necessitate careful management in children with severe underlying cardiac disease.
  • This case highlights the importance of integrated care for pediatric patients with complex comorbidities during viral outbreaks.
  • Close cardiac monitoring and tailored medical interventions are vital for preventing complications in vulnerable pediatric populations.

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
253
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
286
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
224
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
336
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
169
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
253