Related Experiment Video
Updated: Dec 3, 2025

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases
Published on: December 9, 2022
[Pathological and therapeutic possibilities in inhibiting ocular angionesis]
Yousif Subhi, Lasse Jørgensen Cehofski, Anders Højslet Vestergaard
1jakob.grauslund@rsyd.dk.
Abstract:
In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Mechanism of Angiogenesis
Regulation of Angiogenesis and Blood Supply
Angle Closure Glaucoma: Treatment
Glaucoma: Overview

