Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

463
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
463
Hypoxia01:23

Hypoxia

1.7K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.7K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

1.4K
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
1.4K
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

5.1K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
5.1K
Blood Studies I: ABG and VBG01:26

Blood Studies I: ABG and VBG

983
Blood studies are critical in the medical field, enabling healthcare professionals to assess a patient's health status accurately. This page will focus on two significant blood studies: Arterial Blood Gas (ABG) and Venous Blood Gas (VBG).
Arterial Blood Gas (ABG)
Arterial Blood Gas (ABG) studies are crucial for assessing the lungs' ability to supply oxygen and remove carbon dioxide, reflecting the patient's ventilation status. They also help understand the kidneys' capacity to...
983
Hyperpnea and Hyperventilation01:25

Hyperpnea and Hyperventilation

2.0K
Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperbaric Oxygen Treatment as a Novel Add-on in Selected Patients with Infective Endocarditis - A Safety and Feasibility Trial.

Infection and drug resistance·2026
Same author

Prevention of breast cancer-related lymphedema by progressive resistance training - a long-term follow-up of a randomized controlled trial.

Journal of cancer survivorship : research and practice·2026
Same author

Intraoperative Hypotension and Vasoactive Treatment: An International Survey of Anaesthesiologists.

Acta anaesthesiologica Scandinavica·2026
Same author

A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data.

BMC medicine·2026
Same author

Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis.

Critical care (London, England)·2025
Same author

Structural basis for collagen recognition by the <i>Streptococcus pyogenes</i> M3 protein and its involvement in biofilm.

eLife·2025

Related Experiment Video

Updated: Dec 3, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

8.6K

[Hyperbaric oxygen therapy].

Ole Hyldegaard1, Morten Hedetoft

  • 1ole.hyldegaard@regionh.dk.

Ugeskrift for Laeger
|October 29, 2020
PubMed
Summary
This summary is machine-generated.

Fluctuations in oxygen levels, not just low oxygen, activate hypoxia-inducible factor (HIF). This review explores how intermittent hyperoxia in hyperbaric oxygen therapy aids healing and infection control.

More Related Videos

Induction of Cerebral Arterial Gas Embolism in Rat
06:26

Induction of Cerebral Arterial Gas Embolism in Rat

Published on: October 18, 2024

723
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.2K

Related Experiment Videos

Last Updated: Dec 3, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

8.6K
Induction of Cerebral Arterial Gas Embolism in Rat
06:26

Induction of Cerebral Arterial Gas Embolism in Rat

Published on: October 18, 2024

723
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.2K

Area of Science:

  • Physiology
  • Molecular Biology
  • Biomedical Engineering

Background:

  • Hypoxia (low oxygen) is a known trigger for hypoxia-inducible factor (HIF).
  • HIF regulates the transcription of numerous target genes crucial for cellular adaptation.
  • Oxygen fluctuations, including intermittent hyperoxia, also induce HIF transcription.

Purpose of the Study:

  • To review the mechanisms by which intermittent hyperbaric hyperoxia influences biological processes.
  • To correlate these mechanisms with observed outcomes of hyperbaric oxygen therapy (HBOT).
  • To explore the role of oxidative stress in enhancing antibiotic efficacy.

Main Methods:

  • Literature review of studies on hypoxia, hyperoxia, and HIF.
  • Analysis of mechanisms linking oxygen fluctuations to HIF activation.
  • Examination of evidence for HBOT effects on wound healing, angiogenesis, and tissue repair.
  • Review of research on oxidative stress and antibiotic activity.

Main Results:

  • Intermittent hyperoxia, similar to hypoxia, effectively induces HIF transcription.
  • Mechanisms of intermittent hyperbaric hyperoxia may explain HBOT benefits like enhanced wound healing, angiogenesis, and tissue regeneration.
  • Oxidative stress generated during HBOT can potentiate the effectiveness of certain antibiotics.

Conclusions:

  • Oxygen availability fluctuations are significant inducers of HIF transcription.
  • Intermittent hyperbaric hyperoxia offers a mechanistic explanation for therapeutic effects observed in HBOT.
  • Oxidative stress is a key factor in improving antibiotic performance for infection control.