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Related Experiment Video

Updated: Dec 3, 2025

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[Sickle cell disease and pregnancy].

Thomas Christensen1, Amina Nardo-Marino, Andreas Glenthøj

  • 1thomasc87@hotmail.com.

Ugeskrift for Laeger
|October 29, 2020
PubMed
Summary

Sickle cell disease (SCD) in pregnancy poses risks like premature birth and fetal growth issues. This review covers SCD

Area of Science:

  • Hematology
  • Obstetrics
  • Genetics

Background:

  • Sickle cell disease (SCD) is a prevalent severe hereditary blood disorder globally.
  • Pregnancy with SCD increases risks for maternal and fetal complications, including mortality and fetal growth restriction.
  • Increased migration has led to a rise in pregnant women with SCD in regions like Denmark.

Purpose of the Study:

  • To review the etiology, assessment, antenatal care, and treatment of pregnant women with SCD.
  • To provide guidance for managing SCD in pregnancy.

Main Methods:

  • Literature review focusing on SCD in pregnancy.
  • Synthesis of current knowledge on SCD management during gestation.

Main Results:

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  • SCD in pregnancy is linked to significant adverse perinatal outcomes.
  • Comprehensive antenatal care and timely interventions are crucial for improving outcomes.
  • Management requires a multidisciplinary approach.

Conclusions:

  • Pregnant women with SCD require specialized, multidisciplinary care.
  • Early diagnosis and proactive management can mitigate risks associated with SCD during pregnancy.
  • Further research is needed to optimize care protocols.