Particle Formation Mechanisms in the Nanoprecipitation of Polystyrene
Chen Zhao1, Scott Melis1, Eleni P Hughes1
1Department of Physics and Institute for Soft Matter Synthesis and Metrology, Georgetown University, 37th and O Streets NW, Washington DC 200567, United States.
Abstract:
Numerous precipitation methods for creating nanoparticle dispersions that are based on mixing a solution with a miscible nonsolvent have been developed. Here, we show that for polymer particles, the formation is highly dependent on the rate of mixing. We also demonstrate the importance of the glass transition of the polymers on particle formation. A simple model of droplet formation during mixing provides a satisfactory description of the observed dependence of particle size on polymer molecular weight, concentration, solvent ratio, and mixing conditions.
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