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Related Experiment Video

Updated: Dec 3, 2025

Synthesis and Characterization of Supramolecular Colloids

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Controlling Supramolecular Structures of Drugs by Light.

Johannes Wiest¹, Josef Kehrein¹, Marco Saedtler¹

¹Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

Molecular Pharmaceutics

|October 29, 2020

Summary

This study demonstrates light-controlled drug properties using photoswitchable ion pairs. This novel approach enhances drug permeation and physicochemical control for light-unresponsive medications.

Keywords:

NMR light responsive micelle poorly water-soluble drug salt design

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Area of Science:

Supramolecular Chemistry
Materials Science
Photochemistry

Background:

Controlling physicochemical and kinetic properties of light-unresponsive drugs is challenging.
Light-triggered modulation of drug behavior offers a novel therapeutic approach.

Purpose of the Study:

To develop a method for light-controlled manipulation of physicochemical and kinetic properties of light-unresponsive drugs.
To investigate the use of photoswitchable azobenzene counterions for ion pairing with drugs.

Main Methods:

Ion pairing of light-unresponsive drugs (salicylate, ibuprofen) with photoswitchable azobenzene counterions.
Investigation of photoliquefaction into room-temperature ionic liquids under UV light.
Analysis of light-induced changes in supramolecular structures (wormlike aggregates, micelles) in aqueous solutions.

Main Results:

Reversible control over supramolecular structures and drug properties was achieved.
Ion pairs photoliquefied into room-temperature ionic liquids under UV light.
Light-controlled drug permeation through membranes was significantly enhanced (12 h vs. 72 h).

Conclusions:

Azobenzene ion-pairing successfully extends light control to light-unresponsive drugs.
This strategy enables reversible modulation of drug physicochemical and kinetic properties.
The developed method offers a promising avenue for advanced drug delivery systems.