Does thyroid autoimmunity affect the reproductive outcome in women with thyroid autoimmunity undergoing assisted...

Our study aims to investigate whether the anti-thyroperoxidase antibody (TPO-Ab) and TSH level in euthyroid women have any association with reproductive outcomes after the ART cycle.

A total of 1107 patients who were enrolled in the study were divided into four groups based on serum TSH level and TPO-Ab status: group A, 0.3 ≤ TSH < 2.5 mIU/L and TPO-Ab^- ; group B, 0.3 ≤ TSH < 2.5 mIU/L and TPO-Ab⁺ ; group C, 2.5 ≤ TSH < 4.2 mIU/L, and TPO-Ab^- ; and group D, 2.5 ≤ TSH < 4.2 mIU/L, TPO-Ab⁺ . The differences in ART cycles and pregnancy outcomes were analyzed between study groups.

The fertilization rate in group D (73%) was significantly lower than that in groups A (83% P < .001), B (84% P = .001), and C (82% P = .002). The biochemical pregnancy rates of groups B (7%) and D (12%) were significantly higher than those of group A (2%) (P = .028 and P = .017, respectively). TPO-Ab was related to a higher biochemical pregnancy rate (P = .002, OR = 5.311, 95% CI 1.859-15.169) and TSH over 2.5 mIU/L was related to higher ICSI rate (P = .001, OR = 1.759, 95% CI 1.250-2.476) by logistic regression analysis. The receiver operating characteristic (ROC) also verified the results.

The impacts of TSH ≥ 2.5 mIU/L on the intracytoplasmic sperm injection (ICSI) rate, TSH ≥ 2.5 mIU/L and TPO-Ab⁺ on the fertilization rate, and TPO-Ab⁺ on the biochemical pregnancy rate, rather than the effect on abortion, clinical pregnancy, and live birth, were emphasized.