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The values of coagulation function in COVID-19 patients

Xin Jin1,2, Yongwei Duan1,2, Tengfei Bao1,2

  • 1Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Plos One
|October 29, 2020
PubMed

Insights

COVID-19 patients exhibit abnormal blood coagulation. Elevated levels of specific coagulation markers, like t-PAIC and D-Dimer, predict mortality risk and indicate the need for dynamic monitoring.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • COVID-19 is associated with significant morbidity and mortality.
  • Coagulopathy, or abnormal blood clotting, is a recognized complication in severe COVID-19.
  • Understanding coagulation derangements is crucial for managing COVID-19 patients.

Purpose of the Study:

  • To investigate blood coagulation function in COVID-19 patients.
  • To determine the correlation between coagulopathy and COVID-19 disease severity.
  • To identify coagulation parameters predictive of mortality.

Main Methods:

  • Retrospective analysis of 147 clinically diagnosed COVID-19 patients.
  • Measurement of various coagulation markers including TAT, PIC, TM, t-PAIC, PT, INR, APTT, FIB, TT, DD, and PLT.
  • Logistic regression analysis to identify independent risk factors for mortality.

Main Results:

  • COVID-19 patients showed significantly higher levels of TAT, PIC, TM, t-PAIC, PT, INR, FIB, and DD compared to healthy controls.
  • Patients with thrombotic disease had elevated coagulation markers and higher case-fatality.
  • TAT, PIC, TM, t-PAIC, PT, INR, APTT, FIB, DD, and PLT correlated with disease severity.
  • t-PAIC and DD were identified as independent risk factors for mortality.

Conclusions:

  • Most COVID-19 patients present with dysregulated coagulation systems.
  • Dynamic monitoring of coagulation parameters is essential for managing COVID-19.
  • Specific markers like t-PAIC and DD can predict mortality risk in COVID-19 patients.
Abstract

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