The values of coagulation function in COVID-19 patients

Area of Science:

• Hematology
• Infectious Diseases
• Critical Care Medicine

Background:

• COVID-19 is associated with significant morbidity and mortality.
• Coagulopathy, or abnormal blood clotting, is a recognized complication in severe COVID-19.
• Understanding coagulation derangements is crucial for managing COVID-19 patients.

Purpose of the Study:

• To investigate blood coagulation function in COVID-19 patients.
• To determine the correlation between coagulopathy and COVID-19 disease severity.
• To identify coagulation parameters predictive of mortality.

Main Methods:

• Retrospective analysis of 147 clinically diagnosed COVID-19 patients.
• Measurement of various coagulation markers including TAT, PIC, TM, t-PAIC, PT, INR, APTT, FIB, TT, DD, and PLT.
• Logistic regression analysis to identify independent risk factors for mortality.

Main Results:

• COVID-19 patients showed significantly higher levels of TAT, PIC, TM, t-PAIC, PT, INR, FIB, and DD compared to healthy controls.
• Patients with thrombotic disease had elevated coagulation markers and higher case-fatality.
• TAT, PIC, TM, t-PAIC, PT, INR, APTT, FIB, DD, and PLT correlated with disease severity.
• t-PAIC and DD were identified as independent risk factors for mortality.

Conclusions:

• Most COVID-19 patients present with dysregulated coagulation systems.
• Dynamic monitoring of coagulation parameters is essential for managing COVID-19.
• Specific markers like t-PAIC and DD can predict mortality risk in COVID-19 patients.