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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

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Eosinophils in the Tumor Microenvironment.

Fabrizio Mattei¹, Sara Andreone¹, Giancarlo Marone^2,3

¹Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

Advances in Experimental Medicine and Biology

|October 29, 2020

Summary

This summary is machine-generated.

Eosinophils, immune cells in allergies, show potential in cancer immunity. Their tumor microenvironment roles and functions are increasingly recognized, prompting new research into cancer immunology.

Keywords:

Angiogenesis CD8+ T cells Cancer Cationic proteins Cytotoxicity Eosinophil Exosomes Extracellular Traps Immune regulation Lymphangiogenesis Mast cell Mouse models Tumor Immunity Tumor Microenvironment Tumor prognostic value

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Published on: April 12, 2024

Area of Science:

Immunology
Cancer Biology
Cellular Biology

Background:

Eosinophils are immune cells traditionally studied in allergic diseases and parasitic infections.
These cells secrete mediators with potential immunoregulatory activities in the tumor microenvironment (TME).
Recent attention is focusing on the role of eosinophils within the TME in cancer immunity.

Purpose of the Study:

To review the biological functions of eosinophils relevant to the TME.
To discuss eosinophil phenotypic plasticity in response to tumor stimuli.
To analyze eosinophil effector mechanisms in cancer immunity and review preclinical models.

Main Methods:

Literature review of eosinophil functions in inflammation and cancer.
Analysis of eosinophil phenotypic changes and effector mechanisms (degranulation, DNA traps, exosomes).
Review of preclinical models for studying eosinophils in cancer in vivo.

Main Results:

Eosinophils possess diverse biological functions relevant to the TME.
Eosinophils can adopt pro- or antitumorigenic properties based on microenvironmental cues.
Both canonical and unconventional eosinophil mechanisms may influence tumor immune responses.

Conclusions:

Eosinophils are emerging as significant players in cancer immunity.
Understanding eosinophil functions in the TME is crucial for developing novel cancer therapies.
Further research using preclinical models is needed to elucidate the in vivo role of eosinophils in cancer.