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Dendritic Cells in the Tumor Microenvironment

Karan Kohli1, Venu G Pillarisetty2

  • 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Advances in Experimental Medicine and Biology
|October 29, 2020
PubMed

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) of the immune system. They capture foreign antigens and can present them to lymphocytes, that is, T cells and B cells, to activate them. DCs are the most potent of all immune cells at inducing the adaptive immune system. Thus, the presence of DCs at the anatomical site of the immune challenge is imperative for the immune system to mount an effective immune response. From the anatomical site of the immune challenge, DCs cargo antigens to the draining lymph nodes, specialized immune organs where adaptive immunity is generated. DCs are heterogeneous as a type of immune cell, and various subsets of DCs have been reported and their functions described. In this chapter, we discuss various aspects of DC development and function. We further discuss how various tumor microenvironments can affect DC development, function, and migration, thus evading a strong adaptive immune response.

Keywords:
Anti-tumor immunityAntigen-presenting cellsChemotaxisCytokinesDanger signalDendritic cellsDevelopmentImmunosuppressionLongevityLymph nodesMigrationSubsetsTertiary lymphoid organsToll-like receptorsTumor microenvironment

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