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Published on: May 28, 2019
Early prognostic capacity of serum lactate for severe postpartum hemorrhage
Venance Basil-Kway1, Roberto Castillo-Reyther2,3, L Andrés Domínguez-Salgado1
1Department of Clinical Epidemiology, School of Medicine, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico.
Objective:
To evaluate whether the concentration of serum lactate during the diagnosis of postpartum hemorrhage (bleeding ≥500 mL during labor or ≥1000 mL during cesarean delivery) predicts severe hemorrhage (SPPH; blood loss ≥1500 mL at end of labor or in the following 24 h).
Methods:
A prospective cohort pilot study was conducted of women with a vaginal or cesarean delivery from February 2018 to March 2019 who presented with bleeding ≥500 mL measured by the gravimetric method in a reference hospital in San Luis Potosi, Mexico. Venous blood samples were taken for analysis of serum lactate. A receiver operating characteristic curve determined the serum lactate threshold value for SPPH and χ2 test assessed the difference in serum lactate elevation between SPPH and non-SPPH groups. Lastly, the prognostic capacity between the thresholds was compared.
Results:
SPPH developed in 43.33% of the 30 women in the study group. The best prognostic threshold was 2.68 mmol/L of serum lactate (odds ratio [OR] 17.88, 95% confidence interval [CI] 2.7-16.8, P < 0.001); sensitivity was 0.85 (95% CI 0.55-0.98); specificity was 0.76 (95% CI 0.50-0.93).
Conclusion:
Serum lactate may be a useful prognostic marker for SPPH, more studies are needed to validate these findings.
