Related Experiment Video
Updated: Dec 3, 2025
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Pediatric laryngeal sarcoma: Systematic review and pooled analysis
Taha A Mur1, William R Pellegrini2, Zaroug Jaleel2
1Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, MA, USA.
Insights
Pediatric laryngeal sarcoma is rare, with rhabdomyosarcoma being most common. Patient and tumor factors did not impact survival in this review of pediatric soft tissue sarcoma cases.
Area of Science:
- Pediatric oncology
- Laryngeal diseases
- Mesenchymal tumors
Background:
- Sarcomas are rare, diverse tumors of mesenchymal origin affecting all ages.
- Disease site influences survival in sarcoma patients.
- Limited research exists on pediatric laryngeal sarcoma treatment.
Purpose of the Study:
- To analyze existing literature on pediatric laryngeal sarcoma.
- To identify patient and tumor characteristics impacting outcomes.
Main Methods:
- A structured literature review following PRISMA guidelines was conducted.
- Case reports of pediatric (age ≤17) laryngeal sarcoma were identified.
- Data from 37 patients across 29 case reports were analyzed.
Main Results:
- Rhabdomyosarcoma (69.4%) and synovial sarcoma (19.4%) were the most common subtypes.
- The supraglottis was the most frequent tumor subsite (62.1%).
- Survival was not significantly impacted by tumor site, treatment, histology, or gender.
Conclusions:
- Soft tissue sarcoma is uncommon in the pediatric larynx.
- Patient and tumor characteristics did not demonstrate an impact on outcomes.
- High-quality case report documentation is crucial for advancing understanding.
Background:
Sarcomas are a rare, diverse tumor class of mesenchymal origin affecting all age groups. Survival after diagnosis is influenced by disease site. To date, there are no analyses evaluating treatment of pediatric sarcoma within the larynx specifically.
Methods:
A structured literature review following PRISMA guidelines was preformed to identify case reports of pediatric (age 17 and younger) laryngeal sarcoma.
Results:
Twenty-nine case reports documenting 37 pediatric patients diagnosed with sarcoma in the larynx were identified since 1980. The majority of patients were male (79.4%). The most common histological subtypes were rhabdomyosarcoma (69.4%) and synovial sarcoma (19.4%). The supraglottis was the most common site of disease (62.1%) among laryngeal subsites. Only two patients were known to have succumbed to their disease. Overall survival was not statistically impacted by primary site of tumor, treatment strategy, histology or gender.
Conclusions:
Soft tissue sarcoma is rarely found in the pediatric larynx. Patient and tumor characteristics studied were not shown to affect outcomes. Increased documenting of high-quality case reports is needed to advance understanding of this disease.
Related Concept Videos
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion