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Updated: Aug 9, 2026

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility
Published on: April 21, 2022
Retinal vasospastic phenomenon in a known case of systemic lupus erythematosus
Sumita Phatak1, Jilna Jaison1, Manoj Soman2
1Department of Retina and Vitreous, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India.
Abstract:
Retinal vasospasm was visualized in a young female; a known case of systemic lupus erythematosus (SLE) retinopathy with unaffected vision. The fundus fluorescein angiogram showed a cyclical filling and emptying of the retinal vessels which was suggestive of vasospasm and a retinal Raynaud's-like phenomenon with no obvious perfusion deficit. There was retinal thinning involving the superficial layers that was seen on optical coherence tomography (OCT), capillary fill voids on OCT angiography, and retinal surface undulations seen on multicolor imaging. All imaging was performed on Spectralis (Heidelberg, Germany).

