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5-Methyltetrahydrohomofolate
P J O'Dwyer1, B H Wagner, D F Hoth
1Investigational Drug Branch, National Cancer Institute, Philadelphia.
Investigational New Drugs
|January 1, 1987
Abstract:
5-methyltetrahydrohomofolate was developed in the 1970's as an antifolate with the potential to overcome methotrexate resistance. This review summarizes the preclinical and clinical data which have accumulated to date. It is concluded that more recent, better characterized antifolates offer greater potential in achieving the goals for which this drug was introduced.