Polymyxin B-induced rhabdomyolysis: A case report
Ming Ni1,2, Xiangdong Meng3, Limin Wang3
1Department of Clinical Pharmacy, Henan Provincial People's Hospital.
Medicine
|October 30, 2020
Summary
This case report details the first instance of rhabdomyolysis, a rare adverse reaction, linked to Polymyxin B treatment. Prompt cessation of the antibiotic led to symptom resolution, highlighting the need for clinical awareness.
Area of Science:
- Clinical Medicine
- Pharmacology
- Infectious Diseases
Background:
- Polymyxin B is a critical antibiotic for treating extensively drug-resistant Gram-negative bacterial infections.
- While effective, Polymyxin B is known to cause various adverse effects.
- Awareness of potential rare side effects like rhabdomyolysis is crucial for safe clinical use.
Observation:
- A 70-year-old female patient developed bacteremia and pneumonia due to extensively drug-resistant *Acinetobacter baumannii* post-valve replacement surgery.
- Polymyxin B was administered for five days, during which the patient reported muscle pain and weakness.
- Elevated serum creatine phosphokinase and myoglobin levels were observed.
Findings:
- Clinical presentation and laboratory results confirmed rhabdomyolysis.
- Discontinuation of Polymyxin B led to normalization of creatine phosphokinase and myoglobin levels, with significant improvement in muscle pain.
- This confirmed a diagnosis of Polymyxin B-induced rhabdomyolysis.
Implications:
- This study reports the first documented case of rhabdomyolysis associated with Polymyxin B.
- Recognizing this rare adverse reaction is vital for enhancing patient safety during Polymyxin B therapy.
- Clinicians should consider rhabdomyolysis in patients presenting with muscle symptoms during Polymyxin B treatment.
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