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A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance
Published on: October 19, 2018
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Computational Fluid Dynamics (CFD)-Based Optimization of Injection Process during Endoscopic Mucosal Therapy
Mohamad Aghaie Meybodi1, Rohit Saini2, Amirfarhang Mehdizadeh2
1Division of Gastroenterology, Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA.
Bioengineering (Basel, Switzerland)
|October 30, 2020
Summary
Optimizing submucosal injections for endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) is crucial. Computational fluid dynamics (CFD) simulations reveal Eleview® offers superior lifting, with lower injection angles enhancing effectiveness.
Area of Science:
- Gastroenterology
- Biomedical Engineering
- Fluid Dynamics
Background:
- Submucosal injection is vital for gastrointestinal endoscopic resection (EMR, ESD).
- Optimizing injection techniques ensures successful lesion separation from deeper layers.
- Computational fluid dynamics (CFD) offers a novel approach to study injection dynamics.
Purpose of the Study:
- To develop a framework for optimizing submucosal injection techniques using CFD.
- To evaluate the lifting characteristics of different agents (Glycerol, Eleview®, ORISE® gel).
- To investigate the impact of injection angles, dynamics, and temperature on lifting performance.
Main Methods:
- Simulations using computational fluid dynamics (CFD).
- Evaluation of three lifting agents: Glycerol, Eleview®, and ORISE® gel.
- Analysis of static and dynamic injection scenarios with varying angles and temperatures.
Main Results:
- Eleview® demonstrated the highest lifting effect, particularly during initial injection.
- Lower injection angles consistently showed increased lifting characteristics.
- Dynamic injection simulations provided insights into angle modulation effects.
- Temperature was identified as a factor influencing lifting agent performance.
Conclusions:
- CFD is a valuable tool for understanding and optimizing submucosal injection for endoscopic resections.
- Eleview® emerges as a promising agent for enhanced submucosal lifting.
- Injection angle and dynamics significantly impact the effectiveness of submucosal lifting agents.
