Poly(N,N'-Diethylacrylamide)-Based Thermoresponsive Hydrogels with Double Network Structure

Temperature response of double network (DN) hydrogels composed of thermoresponsive poly(N,N'-diethylacrylamide) (PDEAAm) and hydrophilic polyacrylamide (PAAm) or poly(N,N`-dimethylacrylamide) (PDMAAm) was studied by a combination of swelling measurements, differential scanning calorimetry (DSC) and ¹H NMR and UV-Vis spectroscopies. Presence of the second hydrophilic network in DN hydrogels influenced their thermal sensitivity significantly. DN hydrogels show less intensive changes in deswelling, smaller enthalpy, and entropy changes connected with phase transition and broader temperature interval of the transition than the single network (SN) hydrogels. Above the transition, the DN hydrogels contain significantly more permanently bound water in comparison with SN hydrogels due to interaction of water with the hydrophilic component. Unlike swelling and DSC experiments, a rather abrupt transition was revealed from temperature-dependent NMR spectra. Release study showed that model methylene blue molecules are released from SN and DN hydrogels within different time scale. New thermodynamical model of deswelling behaviour based on the approach of the van't Hoff analysis was developed. The model allows to determine thermodynamic parameters connected with temperature-induced volume transition, such as the standard change of enthalpy and entropy and critical temperatures and characterize the structurally different states of water.