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Zinc deficiency in anorexia nervosa
Summary
Adolescents with anorexia nervosa often have low zinc intake, increasing deficiency risk. Zinc supplementation may improve mood and reduce anxiety in these patients.
Area of Science:
- Nutritional Psychiatry
- Clinical Nutrition
- Adolescent Medicine
Background:
- Anorexia nervosa is associated with potential micronutrient deficiencies.
- Zinc is essential for numerous physiological processes, and its deficiency can impact mental health.
Purpose of the Study:
- To evaluate zinc deficiency in adolescents with anorexia nervosa.
- To determine the efficacy of zinc supplementation in improving clinical and biochemical parameters, as well as psychological symptoms.
Main Methods:
- A double-blind, randomized, controlled trial was conducted.
- Dietary intake, urinary zinc excretion, depression, and anxiety levels were assessed.
- Patients received either 50 mg elemental zinc/day or a placebo.
Main Results:
- Adolescents with anorexia nervosa exhibited significantly lower zinc intake (7.7 mg/day) compared to recommended levels (15 mg/day).
- Urinary zinc excretion was significantly lower in the anorexia nervosa group than in controls.
- Zinc supplementation led to significant reductions in depression and anxiety scores.
Conclusions:
- Adolescents with anorexia nervosa are at risk for zinc deficiency due to inadequate intake.
- Zinc supplementation appears to be beneficial in alleviating psychological distress, including depression and anxiety, in this population.