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MiRNA-145 and Its Direct Downstream Targets in Digestive System Cancers: A Promising Therapeutic Target

Yini Ma1, Xiu Cao2, Guojuan Shi1

  • 1The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.

Current Pharmaceutical Design
|October 30, 2020
PubMed

Insights

MicroRNA-145 (miR-145) is crucial in digestive system cancers, impacting cell processes and potentially serving as a diagnostic biomarker. Targeting miR-145 offers a promising therapeutic strategy for these malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are key regulators in disease, including cancer development.
  • Emerging evidence highlights miRNAs as potential cancer biomarkers and therapeutic targets.
  • MicroRNA-145 (miR-145) influences cellular processes like proliferation, differentiation, and apoptosis.

Purpose of the Study:

  • To review the function of miR-145 and its targets in digestive system cancers.
  • To discuss miR-145's role in cancer progression and treatment.
  • To explore miR-145 as a diagnostic biomarker and therapeutic target.

Main Methods:

  • Literature review of recent studies on miR-145 in digestive system cancers.
  • Analysis of miR-145's regulatory mechanisms through its direct target genes.
  • Discussion of potential diagnostic and therapeutic strategies involving miR-145.

Main Results:

  • miR-145 plays significant roles in the progression of digestive system cancers.
  • miR-145 modulates key cellular processes relevant to cancer development.
  • Specific direct targets of miR-145 are involved in its tumor-regulatory functions.

Conclusions:

  • miR-145 is a critical factor in digestive system cancers, influencing multiple cellular pathways.
  • miR-145 holds potential as a valuable biomarker for early diagnosis of digestive system cancers.
  • Targeting miR-145 presents a promising therapeutic avenue for treating digestive system malignancies.
Keywords:
apoptosis.biomarkersdigestive system cancersdirect targetsmiR-145proliferation

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