Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

506
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
506
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

3.5K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

1.1K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.1K
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

2.1K
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
2.1K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

705
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
705
Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

2.2K
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exophytic lobulated swelling of the foot in a young woman.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Beyond the Bilayer: Organization and Interactions in the <i>Arabidopsis thaliana</i> Cell Wall-Plasma Membrane System in Atomistic Simulations.

The journal of physical chemistry. B·2026
Same author

Vascular and lymphatic disorders.

Clinical and experimental dermatology·2026
Same author

Association of Vitamin D Status With Mortality and Microbial Spectrum in Late-Onset Neonatal Sepsis: A Comparative Observational Study.

Cureus·2026
Same author

Petting Zoo Perils: Escherichia coli O157:h7 Associated Hemolytic Uremic Syndrome Secondary to Animal Exposure.

Hemodialysis international. International Symposium on Home Hemodialysis·2026
Same author

Synergistic photocatalytic and adsorptive removal of organic dyes using ZnO-Fe<sub>2</sub>O<sub>3</sub> nanoparticles incorporated into guar gum-carboxymethyl cellulose biopolymer matrix.

International journal of biological macromolecules·2025

Related Experiment Video

Updated: Dec 3, 2025

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.8K

Renovascular Hypertension.

Sai Sudha Mannemuddhu1, Jason C Ojeda2, Anju Yadav3

  • 1Department of Pediatrics, Division of Nephrology, University of Florida-College of Medicine, 1600 Southwest Archer Road, HD-214, Gainesville, FL 32610, USA. Electronic address: https://twitter.com/drM_sudha.

Primary Care
|October 30, 2020
PubMed
Summary
This summary is machine-generated.

Renovascular hypertension (RVH) is a common, underrecognized cause of resistant hypertension. Early diagnosis and management, including angioplasty for some, are vital for preventing severe complications.

Keywords:
Fibromuscular dysplasiaRenal artery stenosisRenal vascular angioplastyRenovascular hypertensionResistant hypertensionSecondary hypertension

More Related Videos

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

5.3K
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

529

Related Experiment Videos

Last Updated: Dec 3, 2025

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.8K
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

5.3K
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

529

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Renovascular hypertension (RVH) is a frequent yet often overlooked cause of difficult-to-manage high blood pressure.
  • Many patients with RVH do not achieve adequate blood pressure control despite using multiple antihypertensive drugs.

Purpose of the Study:

  • To provide a comprehensive overview of renovascular hypertension (RVH).
  • To discuss diagnostic approaches and management strategies for RVH.
  • To highlight the importance of early detection and intervention to improve patient outcomes.

Main Methods:

  • Review of current definitions of hypertension.
  • Discussion of diagnostic methodologies for RVH.
  • Analysis of pharmacologic, nonpharmacologic, and interventional (angioplasty) treatment options.
  • Incorporation of data from clinical trials to support evidence-based recommendations.

Main Results:

  • RVH is a significant contributor to resistant hypertension.
  • Optimal management requires a multi-faceted approach.
  • Timely diagnosis and treatment can mitigate long-term cardiovascular and renal damage.

Conclusions:

  • Prompt identification and management of RVH by primary care physicians and hypertension specialists are crucial.
  • A combination of medical therapy and, in select cases, revascularization can effectively control blood pressure.
  • Evidence-based practice recommendations derived from clinical trials guide RVH management.