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Dextroamphetamine treatment of mania
M J Garvey1, S Hwang, D Teubner-Rhodes
1Department of Psychiatry, Veterans Administration Medical Center, Iowa City, IA 52242.
The Journal of Clinical Psychiatry
|October 1, 1987
Summary
Dextroamphetamine significantly reduced mania symptoms in most patients. This study suggests dextroamphetamine may be a viable treatment option for acute mania with minimal side effects.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Bipolar disorder is a severe mental health condition characterized by mood swings.
- Acute mania is a critical phase of bipolar disorder requiring effective treatment.
Purpose of the Study:
- To investigate the efficacy of dextroamphetamine in treating acute manic episodes.
- To assess the safety and side effect profile of dextroamphetamine for mania treatment.
Main Methods:
- A small cohort of acutely manic patients received dextroamphetamine treatment.
- Mania severity scores were measured before and after treatment.
- Adverse events were systematically recorded.
Main Results:
- Five out of six patients (83%) showed a substantial reduction in mania severity (≥50%).
- Only one patient reported experiencing side effects during the treatment period.
- The observed efficacy and tolerability suggest a positive treatment outcome.
Conclusions:
- Dextroamphetamine demonstrated significant potential as a therapeutic agent for acute mania.
- The findings support further investigation into dextroamphetamine for bipolar mania management.
- Low incidence of side effects indicates a favorable safety profile.