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A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
13:42

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

Published on: July 17, 2012

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Morphine and myocardial ischaemia-reperfusion

Li-Ning Wu1, Rui Hu1, Jun-Ma Yu1

  • 1Institutions: Department of Anesthesiology, The Third Affiliated Hospital of Anhui Medical University, Hefei, 230061, China.

European Journal of Pharmacology
|October 30, 2020
PubMed

Insights

Morphine shows protective effects against myocardial injury from ischemia-reperfusion and heart failure in animal models. It also benefits patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention.

Area of Science:

  • Cardiology
  • Pharmacology
  • Biomedical Science

Background:

  • Coronary heart disease (CHD) is a leading cause of death globally.
  • Myocardial injury from ischemia-reperfusion underlies heart failure in CHD.
  • Morphine, an opioid agonist, is used for pain relief and has shown potential in cardiovascular conditions.

Purpose of the Study:

  • To review the cardioprotective effects of morphine.
  • To examine morphine's impact on myocardial ischemia-reperfusion injury and heart failure models.
  • To assess morphine's role in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • Literature review of studies on morphine's effects in animal models of myocardial ischemia-reperfusion and heart failure.
  • Analysis of clinical data on STEMI patients receiving morphine before or during PCI.
  • Brief description of relevant signaling pathways.

Main Results:

  • Morphine demonstrates protective effects in animal models of myocardial ischemia-reperfusion and chronic heart failure.
  • Morphine administration shows positive effects in STEMI patients undergoing pre-primary percutaneous coronary intervention (pre-PPCI) or PPCI.
  • Involvement of specific signaling pathways in morphine's cardioprotection is noted.

Conclusions:

  • Morphine exhibits significant cardioprotective properties against ischemia-reperfusion injury and heart failure.
  • Morphine may be a beneficial adjunct therapy for STEMI patients undergoing PCI.
  • Further research into morphine's mechanisms and clinical applications in cardiovascular disease is warranted.

Keywords:
Chronic heart failureMorphineMyocardial ischaemia-reperfusionST segment Elevation myocardial infarction

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