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Updated: Dec 3, 2025

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
HPV post-infection microenvironment and cervical cancer
Yi Yuan1, Xushan Cai2, Fangrong Shen3
1Suzhou Institute of Systems Medicine, Suzhou, 215123, China; Department of Laboratory Medicine, Shanghai Tongji Hospital, School of Medicine of Tongji University, Shanghai, 200065, China.
Human papillomavirus (HPV) creates a supportive microenvironment that aids viral persistence and cancer progression. Targeting this post-infection microenvironment (PIM) offers a new strategy for treating cervical cancer.
Area of Science:
- Virology
- Immunology
- Oncology
Background:
- Human papillomavirus (HPV) is the most common sexually transmitted virus globally.
- High-risk HPV types are linked to over 99% of cervical cancer cases.
- HPV-infected cells create a post-infection microenvironment (PIM) crucial for viral persistence and malignant progression.
Purpose of the Study:
- To review the components, characteristics, and effects of the PIM in HPV infections.
- To highlight the potential of targeting the PIM for cervical cancer therapy.
Main Methods:
- This review synthesizes current research on the PIM.
- It examines the interplay between infected cells, immune cells, and host stroma.
- Key PIM components like chemokines, cytokines, extracellular vesicles, and metabolites are analyzed.
Main Results:
- The PIM is established through complex interactions involving cellular and molecular components.
- These interactions promote viral persistence, propagation, and malignant transformation.
- The PIM's role in cervical cancer development is increasingly recognized.
Conclusions:
- Understanding the PIM is critical for comprehending HPV pathogenesis.
- Targeting the PIM presents a promising therapeutic avenue for cervical cancer.
- Further research into PIM modulation could improve treatment outcomes.
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