Sonodynamic therapy-derived multimodal synergistic cancer therapy

Area of Science:

• Oncology
• Nanomedicine
• Biomedical Engineering

Background:

• Sonodynamic therapy (SDT) is an emerging non-invasive treatment for solid tumors.
• Tumor complexity necessitates combination therapies for improved outcomes.
• SDT-based synergistic approaches are gaining traction in cancer research.

Purpose of the Study:

• To comprehensively review SDT-instructed multimodal synergistic cancer therapies.
• To discuss the mechanisms of various SDT-based combination treatments.
• To highlight challenges and future prospects for SDT nanomedicines.

Main Methods:

• Review of representative studies on SDT-based multimodal therapies.
• Detailed discussion of incorporated mechanisms in sono-chemotherapy, sono-radiotherapy, sono-immunotherapy, and sono-chemodynamic therapy.
• Analysis of current challenges and future directions.

Main Results:

• Sonodynamic therapy can be effectively combined with chemotherapy, radiotherapy, immunotherapy, and chemodynamic therapy.
• These multimodal approaches demonstrate enhanced tumor treatment effects.
• Nanomedicine plays a crucial role in advancing SDT-based therapies.

Conclusions:

• SDT-based multimodal synergistic therapy shows significant potential for cancer treatment.
• Further development of SDT nanomedicines is essential for clinical translation.
• This approach holds promise for precision tumor treatment medicine.