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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Acute Pyelonephritis I: Introduction01:27

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Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
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Asepsis01:28

Asepsis

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The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
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Urinary Tract Infection II: Pathophysiology01:25

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

235
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
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Aseptic abscess syndrome.

Hannah Fillman1, Patricio Riquelme2, Peter D Sullivan2

  • 1School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.

BMJ Case Reports
|October 30, 2020
PubMed
Summary
This summary is machine-generated.

A rare complication of Crohn's disease, aseptic abscess syndrome, presented as multiple deep abscesses. High-dose steroids rapidly resolved these abscesses, followed by immunosuppressive therapy for Crohn's disease management.

Keywords:
crohn's diseasegastroenterologyimmunologyinfectious diseasesinflammatory bowel disease

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Area of Science:

  • Gastroenterology
  • Immunology
  • Infectious Diseases

Background:

  • Crohn's disease is a chronic inflammatory bowel disease.
  • Aseptic abscess syndrome is a rare complication of inflammatory bowel disease.
  • Diagnosis can be challenging due to negative cultures.

Observation:

  • A 43-year-old woman with Crohn's disease presented with fever, abdominal pain, and diarrhea.
  • Imaging revealed active colitis and multiple splenic, hepatic, and pulmonary abscesses.
  • Abscesses persisted despite broad-spectrum intravenous antibiotics.

Findings:

  • The patient was diagnosed with aseptic abscess syndrome.
  • Treatment with high-dose intravenous steroids led to rapid clinical improvement.
  • Transition to infliximab and azathioprine resulted in complete resolution of abscesses.

Implications:

  • Aseptic abscess syndrome requires prompt recognition and management distinct from infectious etiologies.
  • Corticosteroids are effective in treating aseptic abscesses in inflammatory bowel disease.
  • Long-term management with immunomodulators and biologics is crucial for preventing recurrence.