Related Experiment Video

Updated: Dec 3, 2025

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
19:16

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis

Published on: March 17, 2010

21.0K

Cystatin C and uncontrolled hypertension

Mehmet Onur Omaygenç1, Özgür Ulaş Özcan1, Beytullah Çakal1

  • 1Department of Cardiology, Faculty of Medicine, İstanbul Medipol University; İstanbul-Turkey.

Anatolian Journal of Cardiology
|October 30, 2020
PubMed

Insights

Elevated serum cystatin C levels indicate a higher likelihood of uncontrolled hypertension, even with normal kidney function markers. This biomarker may help detect subtle renal dysfunction in hypertensive patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Serum cystatin C is a sensitive biomarker for renal function.
  • Elevated cystatin C has been linked to adverse cardiovascular events.
  • Its predictive value for hypertension control requires further investigation.

Purpose of the Study:

  • To investigate the predictive value of serum cystatin C for hypertension control.
  • To assess if serum cystatin C can identify patients with poor blood pressure control.

Main Methods:

  • An observational study involving 1037 adults from rural and urban communities.
  • Participants were grouped based on hypertension diagnosis and control status.
  • Serum cystatin C and creatinine levels were measured and compared between groups.

Main Results:

  • Patients with uncontrolled hypertension had significantly higher serum cystatin C levels compared to those with controlled hypertension (0.98±0.23 mg/L vs. 0.89±0.19 mg/L, p=0.001).
  • Serum creatinine levels did not differ significantly between the groups (0.72±0.20 mg/dL vs. 0.70±0.18 mg/dL, p=0.89).
  • Higher serum cystatin C levels independently increased the probability of uncontrolled hypertension (OR, 1.48; 95% CI, 1.09-5.64; p=0.03).

Conclusions:

  • Serum cystatin C concentrations can detect subtle kidney dysfunction in patients with poor blood pressure control.
  • This is particularly relevant when serum creatinine levels are within the normal range.
  • Serum cystatin C may serve as a valuable biomarker for assessing renal health in hypertensive individuals.
Abstract

More Related Videos

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

10.1K
Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

29.2K

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
273
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
2.1K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
506
Antihypertensive Drugs: Action of β1 Blockers01:17

Antihypertensive Drugs: Action of β1 Blockers

β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
1.8K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
506