Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prospects for cure in leukaemia.

J M Goldman1

  • 1Royal Postgraduate Medical School, Hammersmith Hospital, London.

Journal of Clinical Pathology
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

Chemotherapy effectively induces remission in acute leukemia by targeting cancer cells while sparing healthy ones, though the exact mechanism remains unclear. Treatment options for remission include continued chemotherapy or bone marrow transplantation, with varying success rates and risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia.

Blood·1996
Same author

Overexpression of EVI-1 in blast crisis of chronic myeloid leukemia.

Leukemia·1996
Same author

Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humans.

European journal of immunology·1996
Same author

Phenotype and progeny of primitive adherent human hematopoietic progenitors.

Leukemia·1996
Same author

Expression of the LH2 gene in chronic myeloid leukaemia cells.

Leukemia·1996
Same author

Reverse transcription/polymerase chain reaction (RT/PCR) amplification of very small numbers of transcripts: the risk in misinterpreting negative results.

Leukemia·1996
Same journal

Measurement of microinvasive breast carcinoma in the 6th edition WHO Classification: risk of overstaging and clinical implications.

Journal of clinical pathology·2026
Same journal

Development and internal validation of a multifactorial risk model for predicting disease-free survival in oral squamous cell carcinoma.

Journal of clinical pathology·2026
Same journal

HER2-low as a unique subgroup in breast cancer: insights from neoadjuvant chemotherapy response and survival analysis.

Journal of clinical pathology·2026
Same journal

Polyp-forming Dieulafoy lesion of the rectum.

Journal of clinical pathology·2026
Same journal

Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

Journal of clinical pathology·2026
Same journal

MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

Journal of clinical pathology·2026
See all related articles

Area of Science:

  • Hematology
  • Oncology
  • Stem Cell Biology

Background:

  • Acute leukemia patients present with normal hematopoietic stem cell counts at diagnosis.
  • Chemotherapy achieves remission by eradicating leukemic cells while preserving normal hematopoiesis, a selective mechanism that is not fully understood.

Purpose of the Study:

  • To review current understanding of leukemia treatment strategies.
  • To discuss the efficacy and controversies surrounding post-remission therapies for various types of leukemia.

Main Methods:

  • Review of existing literature on acute and chronic leukemia treatment.
  • Analysis of remission rates and outcomes for chemotherapy and bone marrow transplantation (BMT).

Main Results:

Related Experiment Videos

  • High remission rates (80-95% in children, 50-80% in adults) are achievable with chemotherapy for acute leukemia.
  • Chemotherapy is the preferred post-remission strategy for pediatric acute lymphoblastic leukemia.
  • Allogeneic BMT is recommended for younger adults with acute myeloid leukemia and matched sibling donors; its role in other leukemias is still under investigation.

    • Conclusions:

    • While chemotherapy induces remission in acute leukemias, curative strategies like BMT carry significant risks.
    • Allogeneic BMT offers potential cure for chronic myeloid leukemia but with considerable mortality.
    • Chronic lymphocytic leukemia remains incurable with current therapeutic approaches.