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Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
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On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications

Mikhail Inyushin1, Astrid Zayas-Santiago2, Legier Rojas1

  • 1Department of Physiology, Universidad Central del Caribe, Bayamon, Puerto Rico.

Frontiers in Immunology
|October 30, 2020
PubMed

Insights

Platelets release antimicrobial peptides, similar to amyloid-beta (Aβ) peptides found in other cells. This review suggests platelet-generated Aβ may contribute to various amyloidosis conditions, including Alzheimer's disease.

Area of Science:

  • Immunology
  • Neuroscience
  • Biochemistry

Background:

  • Platelets, like other immune cells, release antimicrobial peptides.
  • Amyloid-beta (Aβ) peptides are implicated in various diseases.
  • The role of platelet-derived Aβ in systemic amyloidosis is under investigation.

Purpose of the Study:

  • To review the literature on antimicrobial peptides released by blood cells.
  • To explore the similarity between these antimicrobials and platelet-derived Aβ.
  • To propose that platelet-generated Aβ amyloidosis is more prevalent than currently recognized.

Main Methods:

  • Literature review and analysis.
  • Comparison of antimicrobial peptides from different cell types.
  • Discussion of animal models for studying platelet-related Aβ.

Main Results:

  • Evidence suggests similarity between platelet-derived Aβ and other antimicrobial peptides.
  • Platelet-generated Aβ may contribute to pathologies such as Alzheimer's disease, Parkinson's disease, glaucoma, and preeclampsia.
  • The systemic Aβ from platelets could play a role in various amyloidosis conditions.

Conclusions:

  • Platelet-generated Aβ peptides may be significant contributors to systemic amyloidosis.
  • Understanding the role of platelet Aβ is crucial for investigating amyloidosis-related health disorders.
  • This research area is rapidly evolving with new experimental findings.
Keywords:
Alzheimer’s diseaseamyloid-betaanimal modelsnatural antibioticsplatelets

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