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Related Experiment Videos

Microinvasive lentigo maligna melanoma.

N S Penneys1

  • 1Department of Dermatology, University of Miami School of Medicine, FL.

Journal of the American Academy of Dermatology
|October 1, 1987
PubMed
Summary
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Microinvasion in lentigo maligna, a form of melanoma, is often missed in standard biopsies. Immunohistochemistry aids in detecting these subtle invasive cells, crucial for accurate staging and prognosis.

Area of Science:

  • Dermatopathology
  • Oncology
  • Melanoma Research

Background:

  • Lentigo maligna is a precursor to lentigo maligna melanoma.
  • Accurate assessment of microinvasion is critical for melanoma staging and treatment planning.
  • Standard histological examination can be challenging for identifying subtle invasive foci in lentigo maligna.

Purpose of the Study:

  • To investigate the prevalence and characteristics of microinvasion in lentigo maligna.
  • To evaluate the utility of S100 protein immunohistochemistry in detecting microinvasion.
  • To highlight the diagnostic challenges associated with identifying invasive atypical melanocytes.

Main Methods:

  • Retrospective analysis of 91 skin biopsy specimens initially diagnosed as lentigo maligna.

Related Experiment Videos

  • Utilized S100 protein immunohistochemistry to identify atypical melanocytes indicative of microinvasion.
  • Measured the depth of invasion for identified microinvasive foci.

    • Main Results:

    • Microinvasion was identified in 14 out of 91 cases (approximately 15.4%).
    • Atypical melanocytes were most frequently found in the papillary dermis, with a mean invasion depth of 0.23 mm (range: 0.10-0.75 mm).
    • Invasive cells were often difficult to detect on routine sections due to spindle cell morphology, solitary or small clusters, or obscuring inflammatory infiltrates.

    Conclusions:

    • Microinvasion in lentigo maligna is often subtle and may be missed on routine histological examination.
    • S100 protein immunohistochemistry is a valuable tool for detecting these superficial invasive foci.
    • Close examination with immunohistochemistry is recommended for lentigo maligna, especially in cases with dermal fibrosis or inflammation.